NutriLab · Ingredient Library
Every ingredient.
Explained plainly.
We believe you should understand exactly what goes into your body — and why. Browse every ingredient we use, what it does, and the science behind it.
Our Approach
Science-backed.
Honestly explained.
Every ingredient is chosen from peer-reviewed clinical research. We translate the science into plain language so you can make truly informed decisions about your health.
Browse by health goal
Sleep
These ingredients support your body's natural sleep rhythms — helping you fall asleep more easily, stay asleep, and wake up feeling restored.
7 ingredients
Sleep Onset / Circadian Rhythm
Melatonin
Your body's natural sleep signal
Melatonin is a hormone your brain already produces at night to signal bedtime. A small supplement dose (0.5 mg) gently reinforces that signal — especially helpful if you struggle to fall asleep, work irregular hours, or travel across time zones. Non-addictive and works with your body's own rhythm.
Consult your doctor if you take prescription sleep medication or sedatives (e.g. Ativan, clonazepam, Zopiclone).
0.5–1 mg PM
L-Theanine
Calms the mind without causing drowsiness
Found naturally in green tea, L-Theanine creates a calm, focused state without sedation. Think of it as a gentle off-switch for an overactive mind — equally useful at bedtime to wind down or during the day to reduce anxious mental chatter.
200 mg PM
L-Tryptophan
The amino acid your body converts into sleep hormones
Tryptophan is why a warm glass of milk can make you sleepy — your body converts it into serotonin and then melatonin, your natural sleep hormone. Supplementing at bedtime supports the entire upstream sleep production chain.
Avoid if you take antidepressants (SSRIs, MAOIs, SNRIs such as Prozac, Zoloft, Effexor) due to risk of serotonin syndrome.
500–1,000 mg PM
Sleep Maintenance / Cortisol Suppression
Ashwagandha 1.5%
Ancient adaptogen for stress and cortisol balance
Ashwagandha helps your body adapt to stress rather than be overwhelmed by it. Clinical trials show it significantly lowers cortisol (the stress hormone) and reduces anxiety. Unlike stimulants, it recalibrates your stress system over several weeks of use.
Consult your doctor if you take thyroid medication (e.g. Synthroid, levothyroxine) or antidepressants.
300 mg PM
GABA
Your brain's primary calming neurotransmitter
GABA is the main 'brake' signal in the brain — it quiets overexcited nerve activity. When anxiety strikes, the brain often has too little GABA to restore balance. Supplementing helps settle an overactive nervous system for better sleep and calm.
250–500 mg PM
Lemon Balm 5:1
A gentle herb for both anxiety and sleeplessness
Lemon balm has been used for centuries to ease restlessness and improve sleep. It works by gently raising GABA levels in the brain — similar in principle to anti-anxiety medications but naturally and without dependence risk.
300–600 mg PM
Hops 2%
The sleep herb best known from beer — without the alcohol
Hop flowers contain natural compounds that calm the nervous system and shorten the time to fall asleep. Works especially well combined with lemon balm, where the two together are more effective than either alone.
300–500 mg PM
Scientific References
Peer-reviewed studies supporting the ingredients above
1.Ferracioli-Oda E et al. PLoS ONE 2013;8(5):e63773. PMID: 23691095. Brzezinski A et al. Sleep Med Rev 2005;9(1):41-50. PMID: 15649737
2.Hidese S et al. Nutrients 2019;11(10):2362. PMID: 31623400. DOI: 10.3390/nu11102362
3.Sutanto CN et al. Crit Rev Food Sci Nutr 2022;62(13):3549-3562. PMID: 33353026. DOI: 10.1080/10408398.2020.1860619
4.Langade D et al. Cureus 2019;11(9):e5797. PMID: 31728244. Chandrasekhar K et al. Indian J Psychol Med 2012;34(3):255-262. PMID: 23439798
5.Hepsomali P et al. Front Neurosci 2020;14:923. PMID: 33041752. DOI: 10.3389/fnins.2020.00923
6.Cases J et al. Mediterr J Nutr Metab 2011;4(3):211-218. DOI: 10.1007/s12349-010-0045-4. Hieu TH et al. Medicine (Baltimore) 2019;98(10):e14830. PMID: 30855463
7.Koetter U et al. Phytother Res 2007;21(9):847-851. PMID: 17562528. DOI: 10.1002/ptr.2167
Stress & Anxiety
From everyday stress to burnout, these ingredients help recalibrate your body's stress response — for greater calm and resilience.
9 ingredients
HPA Axis Recalibration / Cortisol
Ashwagandha 1.5%
Ancient adaptogen for stress and cortisol balance
Ashwagandha helps your body adapt to stress rather than be overwhelmed by it. Clinical trials show it significantly lowers cortisol (the stress hormone) and reduces anxiety. Unlike stimulants, it recalibrates your stress system over several weeks of use.
Consult your doctor if you take thyroid medication (e.g. Synthroid, levothyroxine) or antidepressants.
600 mg AM
Phosphatidylserine
A brain cell building block that also buffers cortisol
Phosphatidylserine is a natural fat making up a large portion of brain cell membranes. It blunts the cortisol spike triggered by stress, protects memory under pressure, and has a strong track record for cognitive performance as we age.
100–200 mg AM
Holy Basil 2%
Sacred Ayurvedic herb for calm and clarity
Known as Tulsi in Ayurvedic medicine, holy basil reduces cortisol and inflammatory stress markers. Users typically describe feeling less emotionally reactive — calmer under pressure — without any sedating effect.
300–600 mg AM
Acute GABA-Mediated Calm
L-Theanine
Calms the mind without causing drowsiness
Found naturally in green tea, L-Theanine creates a calm, focused state without sedation. Think of it as a gentle off-switch for an overactive mind — equally useful at bedtime to wind down or during the day to reduce anxious mental chatter.
200–400 mg AM
GABA
Your brain's primary calming neurotransmitter
GABA is the main 'brake' signal in the brain — it quiets overexcited nerve activity. When anxiety strikes, the brain often has too little GABA to restore balance. Supplementing helps settle an overactive nervous system for better sleep and calm.
250–500 mg AM
Kava Kava 30%
Clinically proven herbal anxiety relief
A Cochrane systematic review — the highest standard of medical evidence — confirmed kava significantly reduces anxiety. It acts on the same brain receptors as anti-anxiety medications, but without addiction risk. Effects within an hour.
Do not combine with alcohol or liver-affecting medications. Avoid if you have liver disease.
100–250 mg AM
Lemon Balm 5:1
A gentle herb for both anxiety and sleeplessness
Lemon balm has been used for centuries to ease restlessness and improve sleep. It works by gently raising GABA levels in the brain — similar in principle to anti-anxiety medications but naturally and without dependence risk.
300–600 mg AM
Burnout & Fatigue Recovery
Magnolia 2%
For when chronic stress has become emotional exhaustion
Magnolia bark compounds reduce cortisol and support serotonin — making it particularly useful for the burned-out, depleted state where stress has become chronic exhaustion. A clinical trial found it reduced cortisol by 18% over four weeks.
200–400 mg AM
SAMe
Replenishes the neurotransmitters that burnout depletes
SAMe (S-Adenosylmethionine) is what your body uses to produce serotonin, dopamine, and other mood-regulating chemicals. Chronic stress uses these up. SAMe directly restores them — with strong clinical evidence for mood support comparable to certain antidepressants.
Avoid if you take antidepressants (SSRIs, MAOIs, SNRIs) or any psychiatric medication.
400–800 mg AM
Scientific References
Peer-reviewed studies supporting the ingredients above
1.Bachour B et al. BJPsych Open 2025;11(1):e22. DOI: 10.1192/bjo.2024.833. Chandrasekhar K et al. Indian J Psychol Med 2012;34(3):255. PMID: 23439798
2.Monteleone P et al. Neuroendocrinology 1992;55(5):537-542. PMID: 1379748. Benton D et al. Nutr Neurosci 2001;4(3):169-178. PMID: 11842880
3.Bhattacharyya D et al. Nepal Med Coll J 2008;10(3):176-179. PMID: 19253862
4.Hidese S et al. Nutrients 2019;11(10):2362. PMID: 31623400. Kimura K et al. Biol Psychol 2007;74(1):39-45. PMID: 16930802
5.Hepsomali P et al. Front Neurosci 2020;14:923. PMID: 33041752. DOI: 10.3389/fnins.2020.00923
6.Pittler MH, Ernst E. Cochrane Database Syst Rev 2003;(1):CD003383. PMID: 12535473. DOI: 10.1002/14651858.CD003383
7.Cases J et al. Mediterr J Nutr Metab 2011;4(3):211-218. DOI: 10.1007/s12349-010-0045-4
8.Talbott SM et al. J Int Soc Sports Nutr 2013;10(1):37. PMID: 23924268. DOI: 10.1186/1550-2783-10-37
9.Papakostas GI et al. Am J Psychiatry 2010;167(8):942-948. PMID: 20595412. Hardy ML et al. Am J Clin Nutr 2003;78(3 Suppl):658S. PMID: 12936955
Cognitive Health
Targeting the specific brain systems that govern memory, focus, and cognitive aging — for sharper thinking at any age.
11 ingredients
Long-Term Memory Consolidation
Bacopa 45%
Ayurvedic herb with modern proof for memory
Used as a brain tonic for over 3,000 years, Bacopa is among the most clinically studied herbs for memory. A 2024 double-blind trial confirmed significant improvements in memory and cognitive skills after 12 weeks. Effects build gradually — expect 8–12 weeks for full benefit.
300–450 mg AM
Phosphatidylserine
A brain cell building block that also buffers cortisol
Phosphatidylserine is a natural fat making up a large portion of brain cell membranes. It blunts the cortisol spike triggered by stress, protects memory under pressure, and has a strong track record for cognitive performance as we age.
100–300 mg AM
Huperzine A
The most potent natural memory compound available
Derived from a Chinese medicinal moss, Huperzine A prevents breakdown of acetylcholine — the brain's primary learning and memory chemical. It works by the same mechanism as Alzheimer's medications, but naturally. Even at micro-doses, clinical trial results are impressive.
Avoid if you take Alzheimer's or dementia medication (e.g. Aricept, Exelon). Do not combine with cholinergic drugs.
50–200 mcg AM
Acute Focus & Attention
L-Theanine
Calms the mind without causing drowsiness
Found naturally in green tea, L-Theanine creates a calm, focused state without sedation. Think of it as a gentle off-switch for an overactive mind — equally useful at bedtime to wind down or during the day to reduce anxious mental chatter.
200 mg AM
Alpha GPC
The fastest-absorbing choline source for focus and learning
Alpha GPC delivers choline — the raw material for acetylcholine, the neurotransmitter responsible for focus and memory. It is the most bioavailable choline form available, entering the brain faster than any other source.
300–600 mg AM
Citicoline
A two-in-one: immediate focus and long-term brain structure
Citicoline provides choline for immediate acetylcholine production (focus and learning) and cytidine, which rebuilds brain cell membranes over time. It also increases dopamine receptors, improving motivation and mental drive.
250–500 mg AM
DMAE
Efficient choline precursor for mental clarity and alertness
DMAE crosses into the brain more efficiently than regular choline, supporting acetylcholine production for focus and alertness. Used in clinical settings for cognitive performance with a relatively fast onset.
300–600 mg AM
Neuroprotection & NGF/BDNF
Lion's Mane 40%
The only food known to stimulate new nerve growth factor
Lion's Mane contains unique compounds (hericenones) that cross into the brain and stimulate Nerve Growth Factor — a protein that helps neurons survive and form new connections. A 2023 trial found improved cognitive performance in healthy adults.
500–1,000 mg AM
Ginkgo Biloba 24/6
250 million years old — still among the best for brain blood flow
Ginkgo improves blood flow to the brain, protects neurons from oxidative damage, and reduces brain inflammation. A 2025 analysis of 27 studies ranked Ginkgo-containing formulas top across memory, executive function, and cognitive flexibility.
Consult your doctor if you take blood thinners or anticoagulants (e.g. warfarin, Eliquis, Xarelto, daily aspirin).
120–240 mg AM
Creatine Monohydrate
Brain fuel — not just for muscles
Neurons use enormous amounts of energy, and creatine replenishes that supply. A 2024 meta-analysis of 16 clinical trials confirmed creatine significantly improves memory and mental processing speed.
3,000–5,000 mg AM
PQQ
The only compound that creates new mitochondria in brain cells
PQQ stimulates the creation of brand-new mitochondria inside cells — including neurons — providing more energy for thinking and focus. Clinical trials show improvements in attention and working memory in middle-aged adults.
10–20 mg AM
Scientific References
Peer-reviewed studies supporting the ingredients above
1.Eraiah MM et al. J Psychiatry Cogn Behav 2024;8:168. DOI: 10.29011/2574-7762.000068. Kongkeaw C et al. J Ethnopharmacol 2014;151(1):528-535. PMID: 24252493
2.Crook TH et al. Neurology 1991;41(5):644-649. PMID: 2027484. DOI: 10.1212/WNL.41.5.644. Duan C et al. Nutrients 2025;17(3):452
3.Yang G et al. PLoS ONE 2013;8(9):e74916. PMID: 24205178. DOI: 10.1371/journal.pone.0074916
4.Gomez-Ramirez M et al. Clin Neuropharmacol 2007;30(1):25-38. PMID: 17272967. Hidese S et al. Nutrients 2019;11(10):2362
5.Kerksick CM et al. Nutrients 2024;16(23):4173. DOI: 10.3390/nu16234173
6.McGlade E et al. Food Nutr Sci 2012;3:769-773. DOI: 10.4236/fns.2012.36103. Wignall ND, Brown ES. Ann Clin Psychiatry 2014;26(1):49-55. PMID: 24490218
7.Dimpfel W et al. Eur J Med Res 2003;8(5):183-191. PMID: 12765886
8.Docherty S et al. Nutrients 2023;15(22):4842. PMID: 38004236. DOI: 10.3390/nu15224842
9.Frontiers in Pharmacology 2025;16:1573034. DOI: 10.3389/fphar.2025.1573034
10.Xu C et al. Front Nutr 2024;11:1424972. DOI: 10.3389/fnut.2024.1424972. Rae C et al. Proc R Soc Lond B 2003;270(1529):2147-2150. PMID: 14561278
11.Itoh Y et al. Funct Foods Health Dis 2016;6(3):169-183. Nakano M et al. Adv Exp Med Biol 2012;154:173-179
Weight Management
Addressing the biology behind weight — blood sugar stability, fat oxidation, appetite signalling, and gut bacteria.
15 ingredients
Insulin Sensitivity & Blood Sugar (primary weight drivers)
Berberine HCl
The natural compound that works like metformin for blood sugar
Berberine activates the same cellular energy switch as the diabetes drug metformin, helping cells absorb glucose more efficiently. A 2025 analysis of 50 clinical trials confirmed it significantly reduces blood sugar, triglycerides, waist circumference, and LDL cholesterol.
Consult your doctor if you take diabetes medication (metformin, insulin, Ozempic), statins, or immunosuppressants. May significantly enhance their effects.
500 mg with meals
Gymnema 25%
The 'sugar destroyer' that curbs cravings and blunts glucose spikes
Gymnema (which literally means 'sugar destroyer' in Hindi) blocks sugar absorption in the intestines before it hits the bloodstream, and also stimulates the pancreas to release more insulin. The result: gentler blood sugar curves and reduced cravings.
400–800 mg with meals
Fenugreek 50%
Slows sugar absorption and naturally supports insulin
Fenugreek contains 4-hydroxyisoleucine, which prompts insulin secretion in response to glucose. Its soluble fibre also slows sugar entry into the bloodstream — together producing measurably gentler post-meal blood sugar curves.
500–1,000 mg with meals
Cinnamon Extract 20:1
Your favourite spice at therapeutic potency
We use Ceylon cinnamon at a potent 20:1 extract. Its polyphenols activate insulin receptors in cells, improving their response to glucose even before a meal. A meta-analysis of 10 trials confirmed reductions in fasting blood sugar, cholesterol, and triglycerides.
250–500 mg with meals
Fenugreek 50%
Slows sugar absorption and naturally supports insulin
Fenugreek contains 4-hydroxyisoleucine, which prompts insulin secretion in response to glucose. Its soluble fibre also slows sugar entry into the bloodstream — together producing measurably gentler post-meal blood sugar curves.
500–1,000 mg with meals
Thermogenesis & Fat Oxidation
EGCG 95%
Green tea's fat-burning compound, concentrated 95%
EGCG prevents breakdown of norepinephrine — the fat-burning hormone — leaving more of it circulating. Our extract is 95% EGCG, far more concentrated than any cup of tea. A meta-analysis confirmed measurable increases in 24-hour energy expenditure.
200–400 mg AM
Carnitine Tartrate
The molecule that physically transports fat into your cells' furnaces
L-Carnitine acts like a molecular shuttle, carrying long-chain fatty acids into mitochondria so they can be burned for energy. Without enough carnitine, fat accumulates instead of being oxidised. Nine clinical trials confirm significantly greater weight loss versus placebo.
500–2,000 mg AM
Coleus Forskohlii 10%
Activates the enzyme that unlocks stored body fat
Forskolin triggers a cascade that activates hormone-sensitive lipase — the enzyme that breaks down stored fat for energy. It also stimulates thyroid hormone production, raising basal metabolic rate. A clinical trial found significant reduction in body fat percentage over 12 weeks.
250 mg AM
Appetite & Satiety
Glucomannan
The fibre that expands in your stomach to create natural fullness
Glucomannan from konjac root absorbs up to 50 times its weight in water, forming a gel that creates genuine physical fullness. It has an authorised health claim from the European Food Safety Authority specifically for weight management.
Take other medications at least 1 hour before or 4 hours after — glucomannan may reduce their absorption if taken simultaneously.
1,000–3,000 mg before meals
Inositol
Especially effective for hormonal and insulin-driven weight gain
Inositol improves how cells respond to insulin signals — particularly valuable for women with PCOS or hormonal-driven weight gain, where insulin resistance and elevated androgens make management very difficult. Multiple trials confirm improvements in BMI, insulin sensitivity, and testosterone levels.
1,000–4,000 mg AM
Garcinia Cambogia 60%
Reduces fat storage and curbs appetite
Garcinia's active compound HCA inhibits an enzyme involved in converting carbohydrates to fat, reducing new fat storage. It also increases serotonin, helping reduce appetite and emotional eating. We use a 60% HCA extract.
500–1,500 mg AM
Microbiome-Mediated Weight Support
Glucomannan (prebiotic)
A clinically studied natural ingredient
Selected based on peer-reviewed clinical evidence.
As above — also prebiotic
Inulin (Chicory)
Prebiotic food for the beneficial bacteria in your gut
Inulin from chicory root selectively feeds Bifidobacterium — the beneficial bacteria in your gut. These bacteria produce butyrate, which fuels intestinal cells, reduces inflammation, and strengthens the gut lining. More good bacteria means better immunity and digestion.
3,000–8,000 mg daily
Psyllium Husk Powder
The gold standard for digestive regularity and cholesterol
Psyllium forms a gentle gel in your digestive tract, normalising bowel movements whether you tend toward constipation or loose stools. It also binds bile acids, reducing cholesterol absorption — earning it an FDA-authorised health claim for heart disease prevention.
Take separately from other medications as it may reduce their absorption.
5,000–10,000 mg daily
Apple Pectin
Soluble fruit fibre that feeds gut bacteria and supports cholesterol
Apple pectin is a soluble fibre that selectively feeds Bifidobacterium, binds bile acids to reduce cholesterol, and slows sugar absorption after meals — a versatile, food-based gut health support ingredient.
1,000–3,000 mg daily
Scientific References
Peer-reviewed studies supporting the ingredients above
1.Liu D et al. Front Pharmacol 2025;16:1572197. DOI: 10.3389/fphar.2025.1572197. Zamani M et al. Front Nutr 2022;9:1013055. DOI: 10.3389/fnut.2022.1013055
2.Kanetkar P et al. J Clin Biochem Nutr 2007;41(2):77-81. PMID: 18193099. DOI: 10.3164/jcbn.2007010
3.Neelakantan N et al. Nutr J 2014;13:7. PMID: 24438170. DOI: 10.1186/1475-2891-13-7
4.Allen RW et al. Ann Fam Med 2013;11(5):452-459. PMID: 24019277. DOI: 10.1370/afm.1517
5.Neelakantan N et al. Nutr J 2014;13:7. PMID: 24438170
6.Hursel R et al. Int J Obes 2009;33(9):956-961. PMID: 19597519. DOI: 10.1038/ijo.2009.135
7.Pooyandjoo M et al. Obes Rev 2016;17(10):970-976. PMID: 27335245. DOI: 10.1111/obr.12436
8.Godard MP et al. Obes Res 2005;13(8):1335-1343. PMID: 16129715. DOI: 10.1038/oby.2005.162
9.Keithley JK, Swanson B. Altern Ther Health Med 2005;11(6):30-34. PMID: 16320857. EFSA J 2010;8(10):1798
10.Unfer V et al. Gynecol Endocrinol 2016;32(7):509-518. PMID: 27307386. DOI: 10.3109/09513590.2016.1146267
11.Onakpoya I et al. J Obes 2011;2011:509038. PMID: 21197150. DOI: 10.1155/2011/509038
12.Chua M et al. Mol Nutr Food Res 2010;54(Suppl 1):S59-65. PMID: 20112290. DOI: 10.1002/mnfr.200900249
13.Roberfroid MB et al. Br J Nutr 2010;104(Suppl 2):S1-63. PMID: 20920376. DOI: 10.1017/S0007114510003363
14.Anderson JW et al. Am J Clin Nutr 1999;71(2):472-479. PMID: 10075331. DOI: 10.1093/ajcn/71.2.472
15.Brownlee IA. Proc Nutr Soc 2011;70(4):449-456. PMID: 21929831. DOI: 10.1017/S0029665111000681
Gut & Digestive Health
Supporting digestive comfort, microbiome balance, and liver health — the foundation of overall wellbeing.
8 ingredients
Digestive Enzymes
Bromelain 2,400 GDU/g
Pineapple's powerful digestive and anti-inflammatory enzyme
Bromelain is a protein-digesting enzyme from pineapple. With meals it reduces bloating and improves protein breakdown. Between meals on an empty stomach, it has a systemic anti-inflammatory effect throughout the body.
Consult your doctor if you take blood thinners or anticoagulants (e.g. warfarin, aspirin, Eliquis).
250–500 mg between meals
Betaine HCl
Restores stomach acid to the levels digestion actually requires
Many people have below-optimal stomach acid, especially with age — leading to bloating, poor protein digestion, and nutrient deficiencies. Betaine HCl gently restores acidity, activating digestive enzymes and improving absorption of B12, iron, and calcium.
Do not use if you have a stomach ulcer, GERD, or take acid-suppressing medication (e.g. omeprazole, Nexium). Start at lowest dose.
650–1,300 mg with meals
Prebiotic & Gut Microbiome
Inulin (Chicory)
Prebiotic food for the beneficial bacteria in your gut
Inulin from chicory root selectively feeds Bifidobacterium — the beneficial bacteria in your gut. These bacteria produce butyrate, which fuels intestinal cells, reduces inflammation, and strengthens the gut lining. More good bacteria means better immunity and digestion.
3,000–8,000 mg daily
FOS
Short-chain prebiotics that rapidly nourish your gut bacteria
Fructooligosaccharides (FOS) resist digestion and reach the colon intact, where they selectively feed Bifidobacterium. They ferment quickly, producing short-chain fatty acids including butyrate, and also enhance calcium absorption.
3,000–8,000 mg daily
Psyllium Husk Powder
The gold standard for digestive regularity and cholesterol
Psyllium forms a gentle gel in your digestive tract, normalising bowel movements whether you tend toward constipation or loose stools. It also binds bile acids, reducing cholesterol absorption — earning it an FDA-authorised health claim for heart disease prevention.
Take separately from other medications as it may reduce their absorption.
5,000–10,000 mg daily
Liver & Detox
Milk Thistle 80%
The liver's most clinically validated protector
Milk thistle's active compound silymarin stabilises liver cell membranes against toxin entry, and stimulates production of new liver cells to replace damaged ones. Cochrane reviews consistently confirm improved liver enzyme levels.
150–420 mg daily
Artichoke 5%
Stimulates bile flow for better fat digestion and cholesterol clearance
Artichoke leaf extract stimulates the liver to produce more bile — needed to break down dietary fats and absorb fat-soluble vitamins. More bile flow means better fat digestion and lower cholesterol absorption. A clinical trial found nearly 19 mg/dl reduction in total cholesterol within six weeks.
320–640 mg daily
Dandelion Root 4:1
A traditional liver tonic with gentle detoxifying properties
Dandelion root stimulates bile production, contains prebiotic inulin for gut bacteria, and provides mild anti-inflammatory phenolic acids. A gentle, food-based approach to daily liver and digestive support.
500–1,000 mg daily
Scientific References
Peer-reviewed studies supporting the ingredients above
1.Brien S et al. Evid Based Complement Alternat Med 2004;1(3):251-257. PMID: 15841258. DOI: 10.1093/ecam/neh035
2.Yago MR et al. Mol Pharm 2013;10(11):4032-4037. PMID: 24011025. DOI: 10.1021/mp4003738
3.Roberfroid MB et al. Br J Nutr 2010;104(Suppl 2):S1-63. PMID: 20920376. DOI: 10.1017/S0007114510003363
4.Roberfroid MB et al. Br J Nutr 2010;104(Suppl 2):S1-63. PMID: 20920376
5.Anderson JW et al. Am J Clin Nutr 1999;71(2):472-479. PMID: 10075331
6.Rambaldi A et al. Cochrane Database Syst Rev 2007;(4):CD003620. PMID: 17943794. DOI: 10.1002/14651858.CD003620.pub3
7.Bundy R et al. Phytomedicine 2004;11(4):338-347. PMID: 15253898. DOI: 10.1016/j.phymed.2003.11.004
8.González-Castejón M et al. Nutr Rev 2012;70(9):534-547. PMID: 22946853. DOI: 10.1111/j.1753-4887.2012.00509.x
Immune & Antioxidant
Strengthening immune defences and protecting cells from the oxidative damage that accelerates aging.
11 ingredients
Immune Modulation
Beta-1,3-Glucans
Puts your immune cells on high alert without triggering inflammation
Beta-glucans from fungal cell walls bind directly to immune cells (macrophages and NK cells), activating them into a heightened state of readiness — increasing the speed and effectiveness of your immune response.
250–500 mg daily
Echinacea Angustifolia 4%
Reduces how often you get sick and how long it lasts
A meta-analysis of 14 randomised controlled trials found echinacea reduced cold incidence by 58% and shortened duration by 1.4 days. We use the Angustifolia species, which has the highest concentration of active alkylamide compounds.
300–500 mg daily
Astragalus 0.4%
Traditional Chinese herb that activates T-cells and NK cells
Used in Chinese medicine for over 2,000 years, astragalus polysaccharides activate T-lymphocytes, NK cells, and interferon production — three pillars of the adaptive immune system. As a bonus, it also activates telomerase, supporting cellular longevity.
500–1,500 mg daily
Reishi Mycelia
The mushroom of immortality — uniquely balances the immune system
Reishi uniquely both activates immune cells when defence is needed and calms excessive immune responses — valuable for low immunity and inflammatory conditions alike. Clinical studies confirm it significantly increases NK cell activity.
500–1,000 mg daily
Cordyceps 16%
The endurance mushroom that improves oxygen efficiency and immunity
Cordyceps increases VO2max (how efficiently you use oxygen) and enhances NK cell activity. Clinical trials in elderly adults show significant improvements in energy, immunity, and exercise tolerance.
500–1,000 mg daily
Antioxidant Defence
Quercetin 95%
Nature's most powerful anti-inflammatory flavonoid
Quercetin is the active compound behind much of the anti-inflammatory benefit in apples, onions, and berries. At 95% standardised extract, it significantly reduces CRP and IL-6 inflammatory markers. It also acts as a zinc ionophore, enhancing antiviral defence.
500–1,000 mg daily
Grapeseed Extract 95%
20× stronger than Vitamin C for vascular and antioxidant protection
Grapeseed OPCs are among the most potent plant antioxidants. They protect collagen from enzyme-driven breakdown, strengthen capillary walls, improve circulation, and reduce blood pressure. Nine clinical trials confirm significant systolic BP reduction.
100–300 mg daily
Resveratrol 50%
Activates the longevity genes linked to red wine's benefits
Resveratrol activates SIRT1 — a longevity gene governing DNA repair, inflammation, and metabolic efficiency — and also activates AMPK, the same pathway as berberine and metformin. Clinical trials confirm improvements in blood sugar, cholesterol, and arterial function.
150–500 mg daily
Astaxanthin
The world's most potent antioxidant by a significant margin
Astaxanthin is 6,000 times stronger than Vitamin C as an antioxidant. Unlike most antioxidants, it crosses both the blood-brain barrier and the blood-retinal barrier, protecting the brain, eyes, and skin simultaneously. Clinical trials confirm significant improvements in skin wrinkles, elasticity, and UV protection.
4–12 mg daily
CoQ10 (Ubiquinol)
Essential cellular energy compound — especially critical on statins
CoQ10 is found in the mitochondria of every cell, where it is essential for ATP production. Your heart has the highest concentration of any organ. Statin medications significantly deplete CoQ10 as a side effect. We use the ubiquinol form — the biologically active, reduced version up to 8× better absorbed than standard CoQ10.
If you take statin medication (e.g. Lipitor, Crestor), CoQ10 supplementation is especially recommended as statins deplete CoQ10 levels.
100–200 mg daily
NAC (N-Acetyl Cysteine)
Replenishes glutathione — the body's master antioxidant
NAC is the direct precursor to glutathione, the most important antioxidant your body produces internally. It scavenges harmful free radicals, reduces NF-κB inflammation, and supports liver detoxification. One of the most validated antioxidant supplements in medicine.
600–1,200 mg daily
Scientific References
Peer-reviewed studies supporting the ingredients above
1.Vetvicka V, Vetvickova J. Ann Transl Med 2015;3(2):16. PMID: 25738143. DOI: 10.3978/j.issn.2305-5839.2015.01.05
2.Shah SA et al. Lancet Infect Dis 2007;7(7):473-480. PMID: 17597571. DOI: 10.1016/S1473-3099(07)70160-3
3.Block KI, Mead MN. Integr Cancer Ther 2003;2(3):247-267. PMID: 15035900. DOI: 10.1177/1534735403256553
4.Jin X et al. PLoS ONE 2012;7(8):e42310. PMID: 22879916. DOI: 10.1371/journal.pone.0042310
5.Panda AK, Swain KC. Afr J Pharm Pharmacol 2011;5(1):9-15. DOI: 10.5897/AJPP10.026
6.Hosseinpour-Niazi S et al. J Am Diet Assoc 2015. DOI: 10.1016/j.jand.2014.10.020
7.Feringa HH et al. J Am Diet Assoc 2011;111(8):1173-1181. PMID: 21802563. DOI: 10.1016/j.jada.2011.05.015
8.Liu Y et al. Am J Clin Nutr 2014;99(6):1514-1521. PMID: 24695890. DOI: 10.3945/ajcn.113.082024
9.Tominaga K et al. Acta Biochim Pol 2012;59(1):43-47. PMID: 22428137
10.Zozina VI et al. Front Pharmacol 2018;9:587. PMID: 29950994. DOI: 10.3389/fphar.2018.00587
11.Samuni Y et al. Biochim Biophys Acta 2013;1830(8):4117-4129. PMID: 23618697. DOI: 10.1016/j.bbagen.2013.04.016
Joint & Bone Health
Providing anti-inflammatory support and the raw materials your joints and bones need to stay strong.
7 ingredients
Joint Support
Boswellia Serrata 65%
Powerful joint anti-inflammatory without stomach side effects
Boswellia resin's active compound AKBA is among the most potent natural anti-inflammatory agents known, shutting down the 5-lipoxygenase enzyme responsible for joint inflammation. Unlike NSAIDs, it doesn't cause stomach ulcers and can be used long-term. Pain relief typically begins within 5–7 days.
300–500 mg daily
Glucosamine Sulfate (K)
The raw material cartilage uses to repair and maintain itself
Glucosamine is a natural compound in your cartilage. Supplementing provides the building blocks for cartilage maintenance and repair. A 3-year clinical trial found it actually slowed joint space narrowing over time — not just masking pain, but potentially slowing deterioration.
Contains potassium. Consult your doctor if you have kidney disease or a potassium-restricted diet.
1,500 mg daily
Chondroitin Sulfate 85%
Keeps cartilage hydrated and prevents enzyme-driven degradation
Chondroitin attracts water into cartilage, keeping it cushioning and resilient, while inhibiting the enzymes that break cartilage down. Combined with glucosamine, it performed equivalently to the prescription anti-inflammatory celecoxib in a major clinical trial.
800–1,200 mg daily
MSM
Bioavailable sulfur for joints, tendons, and connective tissue
Sulfur is the third most abundant mineral in the body and essential for collagen, cartilage, and connective tissue synthesis. MSM is the most bioavailable dietary form of sulfur. It also has direct anti-inflammatory properties — often why people feel better after mineral spring baths.
1,000–3,000 mg daily
Bone Health
Vitamin D3
Essential for calcium absorption — deficient in most Canadians
Vitamin D3 controls how much calcium your intestines absorb. Without it, most dietary calcium passes through unused. Deficiency is extremely common in Canada's northern climate. Beyond bone health, it is critical for immune function, muscle strength, and mood.
1,000–4,000 IU daily
Vitamin K2 (MK7)
Directs calcium into bones rather than arteries
Vitamin K2 activates osteocalcin (which binds calcium into bone) and matrix GLA protein (which removes calcium from artery walls). This ensures calcium goes where you want it — bones — and not where you don't — arteries. The MK-7 form has a 72+ hour half-life for effective once-daily dosing.
Consult your doctor if you take warfarin (Coumadin) or other anticoagulants. May affect blood clotting time.
100–200 mcg daily
Bamboo 70% silica
Plant silica for stronger bones, hair, and nails
Silica from bamboo integrates into collagen cross-links and keratin fibres, strengthening both. It stimulates type I procollagen synthesis. Clinical trials show improvements in hair tensile strength and nail brittleness over several months of consistent use.
100–200 mg daily
Scientific References
Peer-reviewed studies supporting the ingredients above
1.Majeed M et al. J Clin Rheumatol 2019;25(6):e66-e70. PMID: 30985491. DOI: 10.1097/RHU.0000000000000919
2.Towheed TE et al. Cochrane Database 2005;(2):CD002946. PMID: 15846645. DOI: 10.1002/14651858.CD002946.pub2
3.Hochberg MC et al. Ann Rheum Dis 2016;75(1):37-44. PMID: 26474833. DOI: 10.1136/annrheumdis-2014-206836
4.Brien S et al. Osteoarthr Cartilage 2008;16(11):1277-1288. PMID: 18583156. DOI: 10.1016/j.joca.2008.03.002
5.Reid IR et al. J Intern Med 2014;275(3):254-263. PMID: 24215272. DOI: 10.1111/joim.12194
6.Knapen MH et al. Osteoporos Int 2013;24(9):2499-2507. PMID: 23525894. DOI: 10.1007/s00198-013-2325-6
7.Wickett RR et al. Arch Dermatol Res 2007;299(10):499-505. PMID: 17960402. DOI: 10.1007/s00403-007-0796-z
Cardiovascular Health
Supporting healthy cholesterol levels, blood pressure, circulation, and the cellular energy your heart depends on.
5 ingredients
Lipid & Vascular Support
CoQ10 (Ubiquinol)
Essential cellular energy compound — especially critical on statins
CoQ10 is found in the mitochondria of every cell, where it is essential for ATP production. Your heart has the highest concentration of any organ. Statin medications significantly deplete CoQ10 as a side effect. We use the ubiquinol form — the biologically active, reduced version up to 8× better absorbed than standard CoQ10.
If you take statin medication (e.g. Lipitor, Crestor), CoQ10 supplementation is especially recommended as statins deplete CoQ10 levels.
100–200 mg daily
Nattokinase 20,000 FU/g
A natural enzyme that directly dissolves fibrin clots
Nattokinase from fermented soybeans directly dissolves fibrin — the protein that forms blood clots — reducing blood viscosity and arterial stiffness. Unlike most cardiovascular supplements that work indirectly, its action is direct. A clinical trial confirmed significant reductions in blood pressure and fibrinogen.
Do not take if you use blood thinners or anticoagulants (e.g. warfarin, Eliquis, Xarelto, daily aspirin). Significant blood-thinning effect.
100–200 mg (2,000 FU) daily
Hawthorn 1.8%
The heart herb with the deepest clinical evidence base
A Cochrane review of 14 randomised controlled trials found hawthorn extract significantly improved exercise tolerance and reduced cardiac symptoms. It dilates coronary arteries, reduces blood pressure via ACE inhibition, and provides antioxidant protection of vascular walls.
300–900 mg daily
Red Yeast Rice (Ankascin)
Natural cholesterol reduction — with the mycotoxin removed
Red yeast rice contains Monacolin K — naturally occurring lovastatin — which inhibits the same enzyme targeted by statin drugs. We use the Ankascin 568-R strain, verified to be free of citrinin, a mycotoxin found in lower-quality products.
Consult your doctor if you take statin cholesterol medication — additive effect. Monitor liver enzymes with long-term use.
600–1,200 mg daily
Resveratrol 50%
Activates the longevity genes linked to red wine's benefits
Resveratrol activates SIRT1 — a longevity gene governing DNA repair, inflammation, and metabolic efficiency — and also activates AMPK, the same pathway as berberine and metformin. Clinical trials confirm improvements in blood sugar, cholesterol, and arterial function.
150–500 mg daily
Scientific References
Peer-reviewed studies supporting the ingredients above
1.DiNicolantonio JJ et al. Open Heart 2015;2(1):e000326. PMID: 26512330. DOI: 10.1136/openhrt-2015-000326
2.Kim JY et al. Hypertens Res 2008;31(8):1583-1588. PMID: 18971533. DOI: 10.1291/hypres.31.1583
3.Pittler MH et al. Cochrane Database Syst Rev 2008;(1):CD005312. PMID: 18254076. DOI: 10.1002/14651858.CD005312.pub2
4.Liu J et al. Am J Chin Med 2006;34(6):905-913. PMID: 17163578. DOI: 10.1142/S0192415X06004454
5.Liu Y et al. Am J Clin Nutr 2014;99(6):1514-1521. PMID: 24695890
Skin, Hair & Nails
Working at the cellular level to stimulate collagen, hydrate skin from within, and strengthen hair and nails.
8 ingredients
Collagen Synthesis & Skin Structure
Fish Collagen (hydrolyzed)
Bioactive peptides that signal your skin to rebuild from within
Hydrolyzed fish collagen produces specific peptides (Pro-Hyp, Hyp-Gly) that signal skin fibroblast cells to produce new collagen and hyaluronic acid. A meta-analysis of 23 clinical trials with nearly 1,500 participants confirmed significant improvements in skin hydration, elasticity, and wrinkle depth.
2,500–5,000 mg daily
Bovine Hydrolyzed Collagen
The most extensively studied oral collagen for skin and connective tissue
Bovine hydrolyzed collagen provides both Type I and III collagen peptides — the most important structural types for skin, tendons, and bone. A landmark clinical trial found 20%+ wrinkle volume reduction after just 8 weeks at the dose we use.
2,500–5,000 mg daily
Hyaluronic Acid
Oral HA hydrates skin from deep within the dermis
Low molecular weight oral hyaluronic acid crosses into the bloodstream and deposits in the skin's dermal layers, where it can hold up to 1,000 times its weight in water. Clinical trials confirm significant improvements in skin moisture and wrinkle reduction within 12 weeks.
80–200 mg daily
MSM
Bioavailable sulfur for joints, tendons, and connective tissue
Sulfur is the third most abundant mineral in the body and essential for collagen, cartilage, and connective tissue synthesis. MSM is the most bioavailable dietary form of sulfur. It also has direct anti-inflammatory properties — often why people feel better after mineral spring baths.
1,000–3,000 mg daily
Astaxanthin
The world's most potent antioxidant by a significant margin
Astaxanthin is 6,000 times stronger than Vitamin C as an antioxidant. Unlike most antioxidants, it crosses both the blood-brain barrier and the blood-retinal barrier, protecting the brain, eyes, and skin simultaneously. Clinical trials confirm significant improvements in skin wrinkles, elasticity, and UV protection.
4–12 mg daily
Hair & Nails
Biotin 100%
The B-vitamin that hair and nails are built with
Biotin is an essential cofactor for the enzymes that synthesise keratin — the structural protein of hair, nails, and skin. Most effective for people with brittle nails or hair quality issues. Important: high-dose biotin can interfere with certain lab tests — inform your doctor before blood work.
High-dose biotin (5,000 mcg) can interfere with thyroid function and cardiac troponin lab tests. Always inform your doctor and lab if you supplement biotin before blood work.
2,500–5,000 mcg daily
Bamboo 70% silica
Plant silica for stronger bones, hair, and nails
Silica from bamboo integrates into collagen cross-links and keratin fibres, strengthening both. It stimulates type I procollagen synthesis. Clinical trials show improvements in hair tensile strength and nail brittleness over several months of consistent use.
100–300 mg daily
Sebum & Acne Regulation
DIM (Diindolylmethane)
Guides estrogen down the healthier metabolic pathway
DIM, found in cruciferous vegetables, shifts estrogen metabolism toward the protective 2-OH pathway. This makes it valuable for women with PMS, hormonal acne, or perimenopausal symptoms — it doesn't change estrogen levels, it improves how estrogen is processed.
Avoid if you have hormone-sensitive cancer (e.g. ER-positive breast cancer) or are on hormone therapy (tamoxifen, letrozole). Consult your doctor if you take thyroid medication.
100–200 mg daily
Scientific References
Peer-reviewed studies supporting the ingredients above
1.de Miranda RB et al. J Cosmet Dermatol 2021;20(4):1072-1080. PMID: 33742704. DOI: 10.1111/jocd.13097
2.Proksch E et al. Skin Pharmacol Physiol 2014;27(3):113-119. PMID: 24401291. DOI: 10.1159/000355523
3.Oe M et al. Nutr J 2017;16(1):11. PMID: 28219351. DOI: 10.1186/s12937-017-0224-0
4.Barmaki S et al. Dermatol Surg 2012. DOI: 10.1111/j.1524-4725.2012.02479.x
5.Tominaga K et al. Acta Biochim Pol 2012;59(1):43-47. PMID: 22428137
6.Soleymani T et al. Skin Appendage Disord 2017;3(3):166-169. PMID: 28879195. DOI: 10.1159/000477648
7.Wickett RR et al. Arch Dermatol Res 2007;299(10):499-505. PMID: 17960402
8.Thomson CA et al. Breast Cancer Res Treat 2017;165(1):97-107. PMID: 28577051. DOI: 10.1007/s10549-017-4297-3
Energy & Vitality
Supporting healthy mitochondria and the B-vitamin cofactors that keep your energy production running efficiently.
9 ingredients
Cellular Energy Production
CoQ10 (Ubiquinol)
Essential cellular energy compound — especially critical on statins
CoQ10 is found in the mitochondria of every cell, where it is essential for ATP production. Your heart has the highest concentration of any organ. Statin medications significantly deplete CoQ10 as a side effect. We use the ubiquinol form — the biologically active, reduced version up to 8× better absorbed than standard CoQ10.
If you take statin medication (e.g. Lipitor, Crestor), CoQ10 supplementation is especially recommended as statins deplete CoQ10 levels.
100–300 mg daily
Creatine Monohydrate
Brain fuel — not just for muscles
Neurons use enormous amounts of energy, and creatine replenishes that supply. A 2024 meta-analysis of 16 clinical trials confirmed creatine significantly improves memory and mental processing speed.
3,000–5,000 mg daily
NMN
Restores cellular energy levels that decline significantly with age
NAD+ is required by every cell to produce energy — and levels drop up to 50% between ages 40 and 60. NMN is the most efficient precursor for restoring NAD+. Higher NAD+ activates sirtuins, proteins that govern cellular repair and biological aging processes.
250–500 mg daily
NR (Nicotinamide Riboside)
Well-validated NAD+ precursor for cellular energy and longevity
NR raises NAD+ levels via a slightly different pathway than NMN. Clinical trials confirm it significantly increases muscle NAD+ and reduces arterial stiffness. It currently has more published clinical trial data than NMN.
250–500 mg daily
NADH
The activated form of Vitamin B3 — direct mitochondrial fuel
NADH is Vitamin B3 in its active, energy-carrying form. It directly fuels mitochondrial ATP production and supports synthesis of dopamine, norepinephrine, and serotonin. Clinical trials confirm benefits for fatigue and cognitive function.
5–20 mg daily
Cordyceps 16%
The endurance mushroom that improves oxygen efficiency and immunity
Cordyceps increases VO2max (how efficiently you use oxygen) and enhances NK cell activity. Clinical trials in elderly adults show significant improvements in energy, immunity, and exercise tolerance.
500–1,000 mg daily
B-Vitamin Energy Cofactors
Vitamin B12 (Methylcobalamin)
The most common vitamin deficiency with the most impactful correction
B12 deficiency affects an estimated 20–40% of adults, often silently causing fatigue, brain fog, mood changes, and nerve damage over time. Vegetarians and vegans are especially at risk. We use methylcobalamin — the neurologically active form — rather than cheaper cyanocobalamin.
500–2,000 mcg daily
Vitamin B6 (P5P)
Active B6 that powers serotonin, dopamine, and GABA synthesis
Vitamin B6 is a cofactor in over 100 enzyme reactions, including synthesis of the key neurotransmitters serotonin, dopamine, and GABA. We use P5P (pyridoxal-5-phosphate) — the biologically active form your body can use immediately.
25–100 mg daily
Vitamin B5 (Pantethine)
The most bioactive B5 form — essential for energy metabolism
Pantethine is the most active form of Vitamin B5 and a direct precursor to Coenzyme A — essential for fatty acid oxidation and energy production. A meta-analysis of 4 clinical trials confirmed significant reductions in cholesterol and triglycerides.
450–900 mg daily
Scientific References
Peer-reviewed studies supporting the ingredients above
1.Mantle D et al. J Mitochondria Nutraceuticals Innov 2016. Zozina VI et al. Front Pharmacol 2018;9:587. PMID: 29950994
2.Lanhers C et al. Eur J Sport Sci 2017;17(7):821-836. PMID: 27328852. DOI: 10.1080/17461391.2017.1321518
3.Yoshino M et al. Science 2021;372(6547):1224-1229. PMID: 34112658. DOI: 10.1126/science.abe9985
4.Martens CR et al. Nat Commun 2018;9(1):1286. PMID: 29599478. DOI: 10.1038/s41467-018-03421-7
5.Forsyth LM et al. Ann Allergy Asthma Immunol 1999;82(2):185-191. PMID: 10071523. DOI: 10.1016/S1081-1206(10)62595-1
6.Chen S et al. J Altern Complement Med 2010;16(5):585-590. PMID: 20504360. DOI: 10.1089/acm.2009.0226
7.Allen LH. Am J Clin Nutr 2009;89(2):693S-696S. PMID: 19116325. DOI: 10.3945/ajcn.2008.26947B
8.Stough C et al. Hum Psychopharmacol 2011;26(4-5):338-347. PMID: 21688245. DOI: 10.1002/hup.1220
9.Evans M et al. Vasc Health Risk Manag 2014;10:89-100. PMID: 24600231. DOI: 10.2147/VHRM.S57116
Hormonal Balance
Addressing estrogen and testosterone balance, and activating cellular renewal pathways for long-term vitality.
8 ingredients
Hormone Modulation
DIM (Diindolylmethane)
Guides estrogen down the healthier metabolic pathway
DIM, found in cruciferous vegetables, shifts estrogen metabolism toward the protective 2-OH pathway. This makes it valuable for women with PMS, hormonal acne, or perimenopausal symptoms — it doesn't change estrogen levels, it improves how estrogen is processed.
Avoid if you have hormone-sensitive cancer (e.g. ER-positive breast cancer) or are on hormone therapy (tamoxifen, letrozole). Consult your doctor if you take thyroid medication.
100–200 mg daily
Maca 0.6%
Peruvian superfood for hormonal balance and vitality
Maca works on the hypothalamic-pituitary-gonadal axis, improving how your body regulates its own hormones rather than directly altering hormone levels. Clinical trials confirm it improves sexual function, reduces menopausal symptoms in women, and increases libido in men.
1,500–3,000 mg daily
Eurycoma Longifolia 20:1
Clinically proven to raise free testosterone in men
Tongkat Ali inhibits SHBG — a protein that binds testosterone and renders it inactive. By reducing SHBG, more testosterone becomes free and usable. A clinical trial in hypogonadal men found it restored both total and free testosterone to normal ranges within 12 weeks.
200–400 mg daily
Shilajit 50%
Ancient mineral resin that supports testosterone and cellular energy
Shilajit is rich in fulvic acid and minerals. A clinical trial found it raised total testosterone by 23.5% and free testosterone by 19.1% over 90 days. It also increases CoQ10 levels in mitochondria for enhanced cellular energy.
250–500 mg daily
Soy Isoflavones 40%
Plant estrogens that ease menopausal symptoms naturally
Soy isoflavones (genistein and daidzein) are phytoestrogens that gently bind estrogen receptors. A meta-analysis of 17 clinical trials found they significantly reduced hot flash frequency and severity in menopausal women.
Avoid if you have hormone-sensitive cancer (e.g. ER-positive breast cancer, uterine cancer). Consult your doctor if you take thyroid medication.
40–80 mg daily
Longevity & Anti-Aging
Resveratrol 50%
Activates the longevity genes linked to red wine's benefits
Resveratrol activates SIRT1 — a longevity gene governing DNA repair, inflammation, and metabolic efficiency — and also activates AMPK, the same pathway as berberine and metformin. Clinical trials confirm improvements in blood sugar, cholesterol, and arterial function.
150–500 mg daily
NMN
Restores cellular energy levels that decline significantly with age
NAD+ is required by every cell to produce energy — and levels drop up to 50% between ages 40 and 60. NMN is the most efficient precursor for restoring NAD+. Higher NAD+ activates sirtuins, proteins that govern cellular repair and biological aging processes.
250–500 mg daily
Spermidine 3HCl
Triggers deep cellular self-renewal that declines with age
Spermidine induces autophagy — the cellular process that identifies and recycles damaged components. Autophagy naturally declines with age and is now considered a hallmark of biological aging. A large observational study linked higher spermidine intake to significantly lower all-cause mortality.
1–5 mg daily
Scientific References
Peer-reviewed studies supporting the ingredients above
1.Thomson CA et al. Breast Cancer Res Treat 2017;165(1):97-107. PMID: 28577051
2.Gonzales GF et al. Climacteric 2012;15(4):335-340. PMID: 22428137. Brooks NA et al. Andrologia 2008;40(4):247-251. PMID: 18652862
3.Tambi MI et al. Andrologia 2012;44(Suppl 1):226-230. PMID: 21671978. DOI: 10.1111/j.1439-0272.2011.01168.x
4.Pandit S et al. Andrologia 2016;48(5):570-575. PMID: 26395129. DOI: 10.1111/and.12482
5.Taku K et al. Menopause 2012;19(7):776-790. PMID: 22433977. DOI: 10.1097/gme.0b013e3182410159
6.Liu Y et al. Am J Clin Nutr 2014;99(6):1514-1521. PMID: 24695890
7.Yoshino M et al. Science 2021;372(6547):1224-1229. PMID: 34112658
8.Wirth M et al. GeroScience 2021;43(2):833-843. PMID: 33377449. DOI: 10.1007/s11357-020-00310-8
